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Literature summary extracted from
- Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-alpha (2011), FEBS J., 278, 1316-1332.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.B28 | ValboroPro | complete inhibition at 0.05 mM | Homo sapiens |  |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.21.B28 | cell surface | - |
Homo sapiens | 9986 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.B28 | alpha2-antiplasmin + H2O | Homo sapiens | efficiently hydrolysed substrate | ? | - |
? | |
| 3.4.21.B28 | B-type natriuretic peptide + H2O | Homo sapiens | efficiently hydrolysed and mostly preferred substrate | ? | - |
? | |
| 3.4.21.B28 | glucagon-like peptide-1 + H2O | Homo sapiens | slow hydrolysis | ? | - |
? | |
| 3.4.21.B28 | glucose-dependent insulinotropic peptide + H2O | Homo sapiens | slow hydrolysis | ? | - |
? | |
| 3.4.21.B28 | neuropeptide Y + H2O | Homo sapiens | efficiently hydrolysed and mostly preferred substrate | ? | - |
? | |
| 3.4.21.B28 | peptide YY + H2O | Homo sapiens | efficiently hydrolysed substrate | ? | - |
? | |
| 3.4.21.B28 | Substance P + H2O | Homo sapiens | efficiently hydrolysed substrate | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.B28 | Homo sapiens | Q12884 | - |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.B28 | alpha2-antiplasmin + H2O | efficiently hydrolysed substrate | Homo sapiens | ? | - |
? | |
| 3.4.21.B28 | B-type natriuretic peptide + H2O | efficiently hydrolysed and mostly preferred substrate | Homo sapiens | ? | - |
? | |
| 3.4.21.B28 | glucagon-like peptide-1 + H2O | slow hydrolysis | Homo sapiens | ? | - |
? | |
| 3.4.21.B28 | glucose-dependent insulinotropic peptide + H2O | slow hydrolysis | Homo sapiens | ? | - |
? | |
| 3.4.21.B28 | L-Ala-L-Pro-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | L-Ala-L-Pro + 7-amino-4-methylcoumarin | - |
? | |
| 3.4.21.B28 | additional information | does not hydrolyze succinyl-L-Ala-L-Pro-7-amido-4-methylcoumarin and H-Gly-Pro-7-amido-4-methylcoumarin | Homo sapiens | ? | - |
? | |
| 3.4.21.B28 | additional information | the enzyme acts as both a dipeptidyl peptidase and an endopeptidyl peptidase | Homo sapiens | ? | - |
? | |
| 3.4.21.B28 | neuropeptide Y + H2O | efficiently hydrolysed and mostly preferred substrate | Homo sapiens | ? | - |
? | |
| 3.4.21.B28 | peptide YY + H2O | efficiently hydrolysed substrate | Homo sapiens | ? | - |
? | |
| 3.4.21.B28 | Substance P + H2O | efficiently hydrolysed substrate | Homo sapiens | ? | - |
? | |
| 3.4.21.B28 | Z-Gly-L-Pro-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | Z-Gly-L-Pro + 7-amino-4-methylcoumarin | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.B28 | FAP | - |
Homo sapiens |
| 3.4.21.B28 | fibroblast activation protein-alpha | - |
Homo sapiens |
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